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Candin is the only FDA licensed DTH skin test antigen made from Candida albicans. It is potency standardized by DTH skin testing in humans. The Delayed Type Hypersensitivity (DTH) test is used routinely to screen patients' immunocompetence. This simple, cost-effective in vivo method provides information to guide the interpretation of tuberculin skin tests as well as an overview of anergy in patients.
The product is indicated in the assessment of immune responsiveness in clinical situations involving the cellular immune system.
Intact cell-mediated immunity (CMI) requires a complex interaction between lymphocytes, macrophages and cytokines. Various immune disorders and disease processes can alter the CMI response. These include congenital immunodeficiencies, acquired immunodeficiencies, cancer, malnutrition and viral and fungal diseases.
A positive DTH response to Candin indicates that the CMI is functioning properly. Candin is frequently used as a control for tuberculin skin testing to rule out anergy as a possible factor in persons who are skin-test negative to tuberculin.
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